Botulinum neurotoxin injected into rat whiskers migrates to brain. (and rats are less sensitive to BoNT/A than mice or humans) http://www.jneurosci.org/content/28/14/3689.short
The Italians found spread of toxin in 1996: http://www.neurology.org/content/46/4/1158.short
And the rabbits in 1952 B.A.G. (stands for Before Allergan Grants). Researchers in London were aware of how the close cousin Tentanus spread throughout the entire body and they wanted to test if and how BoNT spread to the central nervous system. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1366008/?page=1
Science, a respected journal, reports this peer-reviewed journal article “Botulinum Toxin, Type A: Effects on Central Nervous Symptom” in 1965 B.A.
Abstract reads: This study has demonstrated that type A botulinum toxin has a depressant effect on the cortical electrical activity of anesthetized and unanesthetized monkeys. Simultaneous recordings of vital signs indicated a relative lack of change in the electrocardiogram, respiration, blood pressure, and heart rate during this time. The change in the electroencephalogram appeared cyclic in nature and independent of dose or time. All animals exhibited signs of respiratory failure characterized by a gradual interference with neuromuscular transmission at the diaphragm, and subsequently died an anoxic death.
And if the dead monkeys could talk they would tell you what a horrific slow torturous death they died in showing the spread of botulinum toxin to the central nervous system. When it first hit their veins all the monkeys lost consciousness within 5 minutes and didn’t regain consciousness for one hour. Then they spend the next 3-8 days dying. (Photo credit: Jane Goodall Institute, actual monkey was a rhesus) Their lung muscles were paralyzed. ALL DIED. Fifty years ago the science community knew botulinum toxin killed monkeys. http://www.sciencemag.org/content/147/3661/1036.short
The the wise and immortal words of our friend Deep Throat from the Watergate Scandal “Follow Da Money.” In evaluating publications it is wise to research the authors and determine if there is a financial connection to the research grant funder. When I unearth a 6-digit contribution from a corporation it destroys the credibility for me. No one bites the hand that feeds them. I fondly refer to the BoNT articles in the 1950s and 1960s as B.A. meaning Before Allergan invested so heavily in creating research on their “bioterrorism toxin turned miracle drug.”
Btw, Allergan recently sold for $66 Billion. Yes, B as in boy, billion. That is roughly the personal net worth of two Walton family members. In perspective, Walmart global sales last year were $476 billion supported by 2.2 million employees.“
This healthy suspicion is true of all academic research of which I am intimately aware. Cuts in funding have forced academics to turn to corporations for supplemental funding. President Reagan said “Trust, but verify.” I would shorten it to just “verify.”
Unfortunately the average consumer, or even the brilliant consumer for that matter, has a very slim chance of researching and convincing a doctor of anything contrary to what they have been taught or told verbally by the pharmaceutical rep. (Compound that with the fact the brilliant consumer is likely suffering perplexing symptoms from a mysterious ailment.)
Luckily there is Google Scholar and you can at least print the abstracts and ask your doctor to download the paper for free and review. If they have spare time. If they don’t think you are crazy. If they want to be humbled and proved wrong. (That’s a lot of IFs but don’t let that stop you. It is YOUR health and in YOUR BEST INTEREST to become your own health advocate.)