Cold weather and small fiber neuropathy getting worse

Hi fellow soldiers !So I quit smoking around May because I was in a really bad shape and loosing weight especially muscle fat and within a week I started to get much better .The digestive issues gone ,the energy started to come back and also neuropathy got better .I started to get more engage and even was able to help my mom set up her shop and also help at times with ironing and stuff like that .I thought this is what recovery finally looks like.Around September though I got hit with a bout of weakness and was homebound again .Due to isolation ,loneliness and frustration unfortunately I picked up smoking again .While it did give me a much needed mood boost it also making anxiety and nerve pain worse .But what really always makes things much  worse for me and still happened this time around is the cold weather outside .While I try to limit exposure and don’t go outside much and I also try to push myself for some walks because I don’t want to get decondictioned  I’m still struggling with neuropathy so I was wondering If anyone has found a solution or a remedy that helps ?

Research by Sandi Berwick, PDt., MA Completed

Hello All,

It has been while since I have posted to this site.

I would like to share some good news with Cameron, Annette, this Botox Support Community website, and very special members of this wonderful supportive community.

Please read below:

Journal of Women and Aging  (Routledge, Taylor & Francis Group)

Older women’s negative psychological and physical experiences with injectable cosmetic treatments to the face

Sandi Berwick and Áine Humble

ABSTRACT: Seven women (43 to 64 years old) who had negative or mixed emotions about having Botox and/or facial filler injections to the face to reduce signs of aging were interviewed about the impact of the procedures. Impacts ranged from disappointment to all-encompassing, lingering physical and psychological effects, and some women felt abandoned by the medical industrial complex when they turned to it for help with their symptoms. A feminist phenomenological analysis focused on corporeal, temporal and relational existential modes of being. We describe their bodily experiences as (a) commodified, (b) fractured,  (c) abandoned, ( c) reflective, and (d) transformed.

KEYWORDS: Aging,beauty work; body; body image; gender; older women; phenomenology; qualitative

The journal was first posted online August 11th, 2016.

My apologies for the lateness of this posting. I am unsure if I can post the  journal article on line  because of copy right by the Journal of Women & Aging  – I shall check into this.

Nonetheless, all the best to all, and thank you again!

Sandi Berwick, PDt., MA





Please help me. I’m 16 months out and have been feeling much better. I went to the doctor for a UTI and was prescribed Cipro; 250mg twice a day. Before reading the insert, I took my first dose. There is a black box warning on this stuff!! What have I done. I stopped taking it after that one pill, checked for interactions and there are none, but not only does Cipro cause most of the same side effects that we already have, it also ruptures tendons. It’s been 24 hours and I feel ok, but Cipro symptoms may not appear for weeks or months. Does anyone know anything about this. What I should or shouldn’t do?. please any advice Would be so appreciated. I’m scared to death. Thanks everyone. Prayers and healing to all.

Skin biopsy result?

Hi All,

Could anyone who did skin biopsy for small fibre density tell me please your test result if known?

Surgeon who took a biopsy said I have drasticaly low. Profesor who did tests said the norm is 10.7 and I have 0.58…And sample was taken not 3mm but 1 cm/1,5 cm deep.

I wonder how bad it is?

Could anyone who had this test done let me know so I could compare please? Or maybe anyone know more about it .. i would be very thankful.

thank you

VU x

vi chiedo aiuto e qualche risposta


sono 3 anni e 5 mesi che sto male dopo un’ iniezione di Botox.

lo scoppio massimo dei disturbi è avvenuto dopo 2 anni e mezzo dall’ iniezione.

sto ancora male.

fino a 3 mesi fa non riuscivo neanche a reggermi in piedi ,ora riesco a fare qualche chilometro al giorno ma mi partono poi le contratture alla nuca, all’occhio , alle gambe e al torace con difficoltà respiratorie.

qualcuno mi può se un giorno ci sarà fine a questo calvario ?


Hello everyone there are many people I recall and also unfortunately new ones

🤕Hello everyone there are many people I recall  from the past and also unfortunately new ones on Botoxcommunity.

My name is Jennifer I’ve been off and on this  site  for almost 8 years .   I had my injections before it  Botox was  black labeled.  There have been many changes  concerning botox injections and cosmetic fillers .  None of which have contributed to helping us become healthy again .My story is exhausting so what I will tell you ,the only relief I’m going to get it by writing a book . I have hired a writer it’s going to take some time . There are a lot of legalities when it comes to Botox considering  Allergan monopolizes  the pharmaceutical industry.  I assume they  have acquired more money than the tobacco Industries combined in the last decade  . So if all goes well the title of my book will be


I’m still unsure if I can even use the word( Botoxland). If I legally cannot use the term I will find a title that will stick it to them . A few things I wanted to say after being ostracized for so many years I did finally find a doctor willing to help me and except the reality that Botox is dangerous . The odd thing is he has a practice ,actually he is the founder of three different practices. The  main  Office is a learning center but he actually has an  separate on-site aesthetician/cosmetic office. .   Which sales  Botox another being a cosmetic filler . I tried for many years to get help essentially I gave up for two years then I found this Doctor . Yes he  confided in me that Im the third patient  under his care poisoned by botox. This is in a small city outside of San Diego (Temecula ) California . We’re talking about  One doctor in a small city treating three different people whom had been  poisoned. Imagine throughout the United States big city  and small cities . What is the actual percentage of people are getting sick ? Three of us   In a small town . I can’t comprehend how many   actual poisonings are happening or  have happened to this day .  The pharmaceutical company will make sure that information does not become available to  any person in  any country ! I recently found some information maybe you found it too. There is  a scientist in Italy that tested for the accuracy which Allergan has maintained about the spores being too small to into the brain . I myself knew this to be untrue but it is the Italian scientist who decided to test larger animals that have brains similar to human sizes. I’m not sure if it was a goat or lamb I can’t recall. He did release factual data  indeed the spores were able to enter the brain.  One other thing I read thank God for the Europeans, they were doing research on younger men who were injecting Botox for cosmetic reasons . These young man had not been married or have children yet but the data shows there is  Botox in there semen . The  millennium generation is clueless as well as many other generations . Not unlike tobacco it will take time but I am certain it will be exposed to the public .It’s  a dangerous poison with capabilities to harm people are unknown and limitless .

😂 I would also like  to pay tribute to my  darling late Uncle  Dr. John F.  Delamarter❤️❤️

He recently past of a rare cancer . He will never be forgotten by his family nor the thousands  of people that attended  his funeral . Dr. John F. De Lamarter was a Molecular  Biologist  for over 30 years . He was educated here in California  at the University  California San Diego UCSD . Immediately after receiving his PhD he was hired by  A European company called  Glaxo pharmaceuticals of London  .He’s been there ever sense  calling   Switzerland his home. He spent half  his  career  with Glaxo  pharmaceuticals.  The other half was with the Serano  pharmaceutical company . A year before his passing he received the prestigious award  (SCIENTIST OF THE YEAR)  from Serano pharmaceuticals . I’m telling you this because he warned me about the dangers of Botox . He had many friends and  colleagues  ,some were toxicologists.  He explained to me there list  that all toxicologist use as a guideline . Starting from 1 to 18 of the most dangerous toxins  in the world . While you’d think it would be Cyninade ,Anthrax, Ect . It is not its ,not its BOTCHULISM , the most dangerous deadly toxin known  to man. A tablespoon full of botchulism powder can be turned into a  airosole giving the toxin the capacity to kill  2.5 million people .  Our enemies will not use it for terrorism because it is so dangerous the last country to use it  for chemical warfare was Japan long ago .


I’ll never forget  what he said to me before his death.  He said Jenny


This is a man who was highly respected for his contributions to the studies in finding a cure for cancer ,AIDS and other fatal  diseases . Serano  pharmaceuticals  would fly him to La Jolla California to speak  and lecture for a couple hours .  Then fly him home to Zürich  Switzerland .Shortly before his death ,I recall hthey flew him to Australia to speak to the Parliament .

He wasn’t extremely intelligent ,gentle, kind man. Although  he was wealthy you would never know it.  One of his colleagues spoke at his funeral,with an emphasis on how kind he was. They laughed about how upsetting it was for  my uncle to enestasize a fly. On his last visit to the United States  he knew about his cancer and that it terminal. He only wish was to was rent a sports car and driving along the coast .  Many of his best friends from college lived along Highway 101. My Uncle John was married to a extremely wealthy woman. Whom stood to inherit more money  in the future. But my uncle was a humble man who never cared about material things. His passion  ,was his devotion to finding cures for  uncurable diseases.  We all thought , well this time he’s going to rent a doozy, Lamborghini Bentley, Porsche something like that . But he was true to his character he rented a convertible 2008 mustang . I myself had one  is not an expensive car . He chose this crazy yellow  mustang .  It made him very happy and he was able to visit with his best friends one the last time .🙂

I also recall the words he used to describe botulism poisoning.He called it “AN  ELUSIVE PREDATOR ”

If you have any questions please ask and I will try and respond thank you all .

We  are victims a small percentage only we can  comprehend  one anothers pain ,agony and suffering that has become our lives.🤕

I wish you all the best.  My prayer is for all of us  regain our health once again and live a happy life !


Sincerely Jenny










Good publication on iatrogenic botulism.

Search the site below for botulism. Look for Sept 19, 2016

Good to show your doctors, includes drugs not to take, and some things that have helped the recovery process.

Anti migraine nightmare

My GP recently convinced me to try an anti depressant  – Pamelor/nortriptyline. He thought this would be a good match since it also prevents migraine.  He assured me it was mild, even prescribed to children.  I gave it a try. One 10 mg capsule Saturday night. I woke at 3:30 am with a severe migraine, which I still have and it has been 3 days.  Of course as I did my research, migraine is a side effect. The really scary part is the the half life of this drug is 16-90 hours! That means it could stay in my system for over a week. Before Botox, my body could handle trials such as this. Now , I most certainly react and it is not easy. I know this, but somehow weaken at the possibility of relief.  I pray that one day soon, I can be free of this toxin. From now on , I’ve got to stay  calm, know that my physiology has changed, and say no to drugs!

Has anyone tried Ayurvedic remedies? I’m thinking Asheagandha  for anxiety.

Please let me know .


Hi everyone, I would like to ask those of you who have  lost a weight and maybe keep losing fat if you checked your Leptin level?

One of the side effects of botulinum toxin is metabolism problem – in some leaflets even named as Anorexia.

I have now checked mine because I do eat but still lose fat, and my Leptin level is higher causing  my metabolism work non stop no matter how much I eat. What’s weird I do feel hungry which in Leptin high levels should decrease my apetite.

I wonder if anyone else has similar symptoms?


This is in response to the last post from vu. Prednisone is helping me with autoimmune problems. You could try it and quit if it does not help. Read about thyroid and see that the ranges doctors use are not always optimal. Look up “Stop the Thyroid Madness” and “Root Cause”.

Epilepsy atack

Hi all, I  have been tested for small fibre neuropathy plus motor and autonomic neuropathy. I have done biopsy to confirm it. I am also diagnosed with dysautonomia, for very long time I tried to avoid any medications apart ocasionaly benzodiazepines when I had really bad stiffness. Last week I have been in bed already when just like that my legs start to shake, then I got tremors in my whole body and really bad burning in the back of my neck which went down to my lower back and ribs, the burning was like a fire and I got high temperature in 10 mins. I thought it will go away soon but it went that bad that I ended up in hospital with ” epilepsy like atack” . My daughter could not hold me down and my mother couldn’t check my BP because I was jumping so bad. My face went white and blue around nose and lips , also my hands and arms were white with livedo reticularis all over . In the same time I had huge muscles spasm in my entire body, I could not stand the pain from thightening muscles.
In hospital I had lumbar puncture, blood work and tk of my head. Of course they found nothing , blood  work showed muscles and heart enzymes – CK and troponin t elevated but no heart atack. After few days they came back to normal but my mioglobin is low.
few days later I could feel it coming again so I quickly took diazepam ( two tablets – 4 mg) because I was that scared to have it as  bad again.. this time I have managed to stop this evil tremors quicker but the burning came as bad as that time and this time also in my both arms . I think it is neuropathy geting worse and worse, I have been told to start medication and got pregabalin plus methylprednisolone and I still did not take it because I’m so scared. My muscles and skin keeps atrophying and I have no idea what to do. I am trying to find out if Methylprednisolone could help to stop my tissues wasting and also help my blood vessels which are also wasting! The nurse who gives me IV fluids said I have no blood in my veins and they are breaking cause are so weak.
I also have very low blood flow to my head and neck, I wake up flat and white with terrible pain in te back of head and it is worse day by day.
I wonder if it is not some kind of autoimmune reaction in my tissues because I had lots of rashes and IgE elevated which is when there is allergic reaction. I have done lots of autoantibodies tests but nothing has been found apart that IgE and anti TPO – 1300
but all endocrinologists says I dont need treatment for Hashimoto as long as my ft3, ft4 and TSH are normal..
I am very bad and keep deteriorating and I feel lost. The time does not do good for me , it is actually oposite. I have dents in my legs, on my belly on both sides  under my ribs , chest, back, neck, my hands and feet look like anorexia patient and my face is almost gone. I have lost and continue losing all fat from everywhere. Skin, hair, nails are dry and look like ischemic. My legs still get blue in standing from blood pooling down.
Please if anyone tried or heard that steroids like prednisolone or Methylprednisolone helped to anyone please could you let me know.. or maybe there is anything else that helps..
i have also checked my vit b12 and it is too much in my blood , like it does not get into my tissues but circulate in blood.
I forgot to write that my CRP nad OB is higher  now, not much but it is and I also suffer from pain in my all joints but again no any antibodies been found.  I lose my hearing and vission is so much worse too.  My skin on the face look like there is no blood , brows dont grow back and skin is red infamed and peels off. I am almost bald now.

I was so hope it will get better in time but In my case I am more sick.  I am now 26 months out.

God bless you all..


I have small fiber neuropathy from the neck down after receiving botox between eyebrows and filler in face and under eyes in April.  I want to know if anyone takes anything like lyrica or neuron tin and if they have seen any improvement in symptoms over time. I am really having a hard time with this and am now on anti depressants and sleep meds. Any encouragement would be welcome


Attorney. Lawyer. Lawsuit. Message me.

Hello. I’m now 11 months out from my terrible botox experience. I’m looking for people with similar experiences as me who would be willing to let me give their information (or their situation, date of injection, diagnosis etc to start) when contacting attorneys.  Following detrimental botox injections I was hospitalized with botulism as well as autonomic dysfunction and respiratory failure on exertion as well as abnormal heart rhythms. After 3 months of home oxygen I was then diagnosed with heart failure. I’m still on medications to help and have an array of other side effects. 11 months out I’m positive I have permanent damage and I’d like to pursue this. Please email me privately on here. Thank you.

Brand New Article proving what we already know

Botulinum toxin may travel further than expected in nerve cells

August 4, 2016 By David Tenenbaum

The botulinum toxins are among the deadliest substances on Earth, and two specific toxins — including the popular drug Botox — have multiple uses for treating many neuromuscular conditions, including frown lines, disabling muscle spasms and migraine headaches.

The botulinum toxins cancel nerve signals to the muscles, creating paralysis that can last for months. Given its extraordinary toxicity, doses are typically measured in trillionths of a gram, and targets are carefully chosen to silence only the desired motor nerves.

When Botox and related botulinum drugs entered the market, “the idea was that they are safe to use, they stay where they are injected, and you don’t have to worry about toxin going to the central nervous system and causing weird effects,” says Edwin Chapman, an investigator at the Howard Hughes Medical Institute and professor of neuroscience at the University of Wisconsin—Madison.

Photo: Edwin Chapman

Edwin Chapman

The concern that this powerful toxin can move beyond the injection site was reinforced in 2009, when the Food and Drug Administration added a prominent warning to prescribing information “to highlight that botulinum toxin may spread from the area of injection to produce symptoms consistent with botulism,” including “unexpected loss of strength or muscle weakness. … Understand that swallowing and breathing difficulties can be life-threatening and there have been reports of deaths related to the effects of spread of botulinum toxin.”

Additionally, physicians have seen puzzling results from treatment, adds Ewa Bomba-Warczak, a doctoral candidate in neuroscience. “In many cases, after an injection for a disabling spasm of neck muscles called cervical dystonia, there is no change in muscle tone but the patient finds relief and is perfectly happy. That result can’t be explained by the local effects.”

In a study published today (Aug. 4, 2016) in Cell Reports, senior author Chapman, first author Bomba-Warczak and colleagues present clear evidence that toxin is moving between neurons in a lab dish.

The study looked at mouse neurons in wells connected by tiny channels that allow growth of axons — the long fibers that neurons use to communicate.

Photo: Ewa Bomba-Warczak:

Ewa Bomba-Warczak

Photo: Jason Vevea

Jason Vevea

In tests of two botulinum toxins, the researchers saw toxin molecules entering the injected cell, as expected.

Once inside a neuron, botulinum toxin cleaves proteins responsible for fusion of chemical containers, known as vesicles, with the plasma membrane. This fusion event releases chemical signals that underlie communication with muscles, and the inability to fuse leads to the temporary paralysis caused by botulinum toxin.

Using antibodies to identify fragments of the damaged proteins, Chapman’s group showed that toxin molecules were moving to nerve cells in wells that had not initially received the harmful molecules. “Every time one fraction of the toxin acts locally (on the first nerve cell it contacts), another fraction acts at a distance,” says Chapman. “It’s unknown how far they travel, which likely depends on the dose of toxin and other factors.”

Co-author Jason Vevea, a UW–Madison postdoctoral fellow, produced videos showing tagged molecules of botulinum toxin moving along the axons connecting neurons.

Botulinum toxins were first described in the 1800s, and have long been a subject of research at UW–Madison. Allergan PLC, which markets four versions of botulinum toxin, reported global Botox sales of nearly $2 billion in 2015.

Graphic: Botulinum diagram

Injected botulinum toxin is taken up in axons and reaches the cell body, shown in green, before being transported into different neurons, shown in red. DIAGRAM: EWA BOMBA-WARCZAK

By finding that toxin molecules don’t always stay where they are injected, Chapman says the Wisconsin study answers a long-standing question about mobility, but raises several more. “We have seen that these toxins enter neurons at the injection site, causing the desired local paralysis, but Ewa and Jason have shown unambiguously the existence of a second entry pathway that takes some of the toxin molecules to other neurons.”

The research, done in a lab dish, removes variables that have plagued similar studies performed in animals, Chapman says. “We wanted to see if we could build an in vitro (in a dish) system that allows direct visualization of this putative movement, in a way that’s simple, easy to interpret, and unambiguous. Do they move, or do they not?”

Chapman wonders about the effects of extraordinarily powerful toxin molecules that travel the neural networks. Local effects have, until now, been deemed the sole effects. But could part of its effects be due to the transported toxin?

“It’s an exciting prospect, supplanting a $2 billion drug with a safer drug.”

Edwin Chapman

These questions could be answered by genetically engineering the Clostridium bacteria that make botulinum toxin to alter the toxin’s structure, Chapman says. “We may be in a position to mutate the part of the toxin that attaches to a receptor on the neuron so it can only enter the local pathway, not this new pathway we have described.”

If only the local effects matter for medicine, tomorrow’s versions of this ancient toxin molecule may be able to alleviate symptoms from wrinkles to severe muscle spasms without moving beyond the target neurons.

“I have a hard time imagining that any physician is going to want to inject something they know can move about when they have an option to use something that stays put,” Chapman says. “It’s an exciting prospect, supplanting a $2 billion drug with a safer drug.”

– See more at:

Botulinum toxin may travel further than expected in nerve cells

Seeking help…

Is there anyone located in Oregon with advice for ongoing adverse affects from Botox? I have been to every doctor I could get in to. GP, neurologist, Psychiatrist, ER .  None of which have any ideas, answers or advice.  I suffer from severe anxiety, aches in my bones, muscle atrophy, weight loss (40#), no appetitive, chest pain, and nausea. I am 6 months out from last Botox injections. Will this ever end? This is truly a nightmare. If only there were a doctor that would show an interest in figuring this out. I have called Allergan several times. Their answer, “We recommend you contact your provider for this, we have no data to support your symptoms.” Oh my gosh!  Is there any research going on? It seems there are a lot of people suffering.

Someone, please help!